Publication Beamlines
Ereño-Orbea, June; Sicard, Taylor; Cui, Hong; Carson, Jacob; Hermans, Pim; Julien, Jean-Philippe (2018). Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. Journal of Molecular Biology 430(3) , 322-336. 10.1016/j.jmb.2017.12.010. [PDB: 6ana, 6and, 6ani] CMCF-ID
Gong, Hua; Weinstein, David S.; Lu, Zhonghui; Duan, James J.-W.; Stachura, Sylwia; Haque, Lauren; Karmakar, Ananta; Hemagiri, Hemalatha; Raut, Dhanya Kumar; Gupta, Arun Kumar; Khan, Javed; Camac, Dan; Sack, John S.; Pudzianowski, Andrew; Wu, Dauh-Rurng; Yarde, Melissa; Shen, Ding-Ren; Borowski, Virna; Xie, Jenny H.; Sun, Huadong; D'Arienzo, Celia; Dabros, Marta; Galella, Michael A.; Wang, Faye; Weigelt, Carolyn A.; Zhao, Qihong; Foster, William; Somerville, John E.; Salter-Cid, Luisa M.; Barrish, Joel C.; Carter, Percy H.; Dhar, T.G. Murali (2018). Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity. Bioorganic & Medicinal Chemistry Letters 28(2) , 85-93. 10.1016/j.bmcl.2017.12.006. [PDB: 6bns] CMCF-ID
Gorelik, Alexei; Illes, Katalin; Nagar, Bhushan (2018). Crystal structure of the mammalian lipopolysaccharide detoxifier. Proceedings of the National Academy of Sciences , 201719834. 10.1073/pnas.1719834115. [PDB: 5w78, 5w7d] CMCF-ID
Ozer, Hatice Gulcin; El-Gamal, Dalia; Powell, Ben; Hing, Zachary A.; Blachly, James S.; Harrington, Bonnie; Mitchell, Shaneice; Grieselhuber, Nicole R.; Williams, Katie; Lai, Tzung-Huei; Alinari, Lapo; Baiocchi, Robert A.; Brinton, Lindsey; Baskin, Elizabeth; Cannon, Matthew; Beaver, Larry; Goettl, Virginia M.; Lucas, David M.; Woyach, Jennifer A.; Sampath, Deepa; Lehman, Amy M.; Yu, Lianbo; Zhang, Jiazhong; Ma, Yan; Zhang, Ying; Spevak, Wayne; Shi, Songyuan; Severson, Paul; Shellooe, Rafe; Carias, Heidi; Tsang, Garson; Dong, Ken; Ewing, Todd; Marimuthu, Adhirai; Tantoy, Christina; Walters, Jason; Sanftner, Laura; Rezaei, Hamid; Nespi, Marika; Matusow, Bernice; Habets, Gaston; Ibrahim, Prabha; Zhang, Chao; Mathé, Ewy A.; Bollag, Gideon; Byrd, John C.; Lapalombella, Rosa (2018). BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor. Cancer Discovery , CD-17-0902. 10.1158/2159-8290.cd-17-0902. CMCF-ID
Ulaganathan, ThirumalaiSelvi; Helbert, William; Kopel, Moran; Banin, Ehud; Cygler, Miroslaw (2018). Structure–function analyses of a PL24 family ulvan lyase reveal key features and suggest its catalytic mechanism. Journal of Biological Chemistry , jbc.RA117.001642. 10.1074/jbc.ra117.001642. [PDB: 6byx, 6byt] CMCF-BM, CMCF-ID
Abbas, Yazan M.; Laudenbach, Beatrice Theres; Martínez-Montero, Saúl; Cencic, Regina; Habjan, Matthias; Pichlmair, Andreas; Damha, Masad J.; Pelletier, Jerry; Nagar, Bhushan (2017). Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations. Proceedings of the National Academy of Sciences 114(11) , E2106-E2115. 10.1073/pnas.1612444114. [PDB: 5udi, 5udk, 5udl] CMCF-ID
Boniecki, Michal T.; Freibert, Sven A.; Mühlenhoff, Ulrich; Lill, Roland; Cygler, Miroslaw (2017). Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nature Communications 8(1) . 10.1038/s41467-017-01497-1. [PDB: 5wkp, 5wlw] CMCF-ID
Cook, Jonathan D.; Sultana, Azmiri; Lee, Jeffrey E. (2017). Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment. Proceedings of the National Academy of Sciences , 201617993. 10.1073/pnas.1617993114. [PDB: 5t96, 5t9y] CMCF-ID
Copp, William; Denisov, Alexey Y.; Xie, Jingwei; Noronha, Anne M.; Liczner, Christopher; Safaee, Nozhat; Wilds, Christopher J.; Gehring, Kalle (2017). Influence of nucleotide modifications at the C2 prime position on the Hoogsteen base-paired parallel-stranded duplex of poly(A) RNA. Nucleic Acids Research . 10.1093/nar/gkx713. [PDB: 5vxq] CMCF-ID
Crawford, Terry D.; Audia, James E.; Bellon, Steve; Burdick, Daniel J.; Bommi-Reddy, Archana; Côté, Alexandre; Cummings, Richard T.; Duplessis, Martin; Flynn, E. Megan; Hewitt, Michael; Huang, Hon-Ren; Jayaram, Hariharan; Jiang, Ying; Joshi, Shivangi; Kiefer, James R.; Murray, Jeremy; Nasveschuk, Christopher G.; Neiss, Arianne; Pardo, Eneida; Romero, F. Anthony; Sandy, Peter; Sims, Robert J.; Tang, Yong; Taylor, Alexander M.; Tsui, Vickie; Wang, Jian; Wang, Shumei; Wang, Yongyun; Xu, Zhaowu; Zawadzke, Laura; Zhu, Xiaoqin; Albrecht, Brian K.; Magnuson, Steven R.; Cochran, Andrea G. (2017). GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Medicinal Chemistry Letters 8(7) , 737-741. 10.1021/acsmedchemlett.7b00132. [PDB: 5v84] CMCF-ID
Curtin, Michael L.; Pliushchev, Marina A.; Li, Huan-Qiu; Torrent, Maricel; Dietrich, Justin D.; Jakob, Clarissa G.; Zhu, Haizhong; Zhao, Hongyu; Wang, Ying; Ji, Zhiqin; Clark, Richard F.; Sarris, Kathy A.; Selvaraju, Sujatha; Shaw, Bailin; Algire, Mikkel A.; He, Yupeng; Richardson, Paul L.; Sweis, Ramzi F.; Sun, Chaohong; Chiang, Gary G.; Michaelides, Michael R. (2017). SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorganic & Medicinal Chemistry Letters 27(7) , 1576-1583. 10.1016/j.bmcl.2017.02.030. [PDB: 5u69, 5u6d] CMCF-ID
Eastman, Kyle J.; Parcella, Kyle; Yeung, Kap-Sun; Grant-Young, Katharine A.; Zhu, Juliang; Wang, Tao; Zhang, Zhongxing; Yin, Zhiwei; Beno, Brett R.; Sheriff, Steven; Kish, Kevin; Tredup, Jeffrey; Jardel, Adam G.; Halan, Vivek; Ghosh, Kaushik; Parker, Dawn; Mosure, Kathy; Fang, Hua; Wang, Ying-Kai; Lemm, Julie; Zhuo, Xiaoliang; Hanumegowda, Umesh; Rigat, Karen; Donoso, Maria; Tuttle, Maria; Zvyaga, Tatyana; Haarhoff, Zuzana; Meanwell, Nicholas A.; Soars, Matthew G.; Roberts, Susan B.; Kadow, John F. (2017). The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. MedChemComm . 10.1039/c6md00636a. [PDB: 5twn] CMCF-ID
Eble, Johannes A.; McDougall, Matthew; Orriss, George L.; Niland, Stephan; Johanningmeier, Benjamin; Pohlentz, Gottfried; Meier, Markus; Karrasch, Simone; Estevão-Costa, Maria Inacia; Martins Lima, Augusto; Stetefeld, Jörg (2017). Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively. PLoS Biology 15(7) , e2001492. 10.1371/journal.pbio.2001492. [PDB: 5thp] CMCF-ID
El-Halfawy, Omar M.; Klett, Javier; Ingram, Rebecca J.; Loutet, Slade A.; Murphy, Michael E. P.; Martín-Santamaría, Sonsoles; Valvano, Miguel A. (2017). Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. mBio 8(2) , e00225-17. 10.1128/mbio.00225-17. [PDB: 5ixg, 5ixh] CMCF-ID
Ereño-Orbea, June; Sicard, Taylor; Cui, Hong; Mazhab-Jafari, Mohammad T.; Benlekbir, Samir; Guarné, Alba; Rubinstein, John L.; Julien, Jean-Philippe (2017). Molecular basis of human CD22 function and therapeutic targeting. Nature Communications 8(1) . 10.1038/s41467-017-00836-6. [PDB: 5vkj, 5vkk, 5vkm, 5vl3] CMCF-ID